By R. Thorus. College of the Ozarks.
However buy 5 mg atorlip-5 with mastercard, adaptation to a fat and protein fuel requires considerable metabolic adjustments 5 mg atorlip-5 fast delivery. The only cells that have an absolute requirement for glucose as an oxidizable fuel are those in the central nervous system (i. The central nervous system can adapt to a dietary fat-derived fuel, at least in part (Cahill, 1970; Sokoloff, 1973). Also, the glycolyzing cells can obtain their complete energy needs from the indirect oxidation of fatty acids through the lactate and alanine-glucose cycles. In the absence of dietary carbohydrate, de novo synthesis of glucose requires amino acids derived from the hydrolysis of endogenous or dietary protein or glycerol derived from fat. Therefore, the marginal amount of carbohydrate required in the diet in an energy-balanced state is condi- tional and dependent upon the remaining composition of the diet. Never- theless, there may be subtle and unrecognized, untoward effects of a very low carbohydrate diet that may only be apparent when populations not genetically or traditionally adapted to this diet adopt it. Of particular concern in a Western, urbanized society is the long-term consequences of a diet sufficiently low in carbohydrate such that it creates a chronically increased production of β-hydroxybutyric and acetoacetic acids (i. The concern is that such a diet, deficient in water- soluble vitamins and some minerals, may result in bone mineral loss, may cause hypercholesterolemia, may increase the risk of urolithiasis (Vining, 1999), and may affect the development and function of the centra1 ner- vous system. It also may adversely affect an individual’s general sense of well being (Bloom and Azar, 1963), although in men starved for an extended period of time, encephalographic tracings remained unchanged and psychometric testing showed no deficits (Owen et al. The latter is required for hypoglycemic emergencies and for maximal short-term power production by muscles (Hultman et al. Glucose production has been deter- mined in a number of laboratories using isotopically labeled glucose (Amiel et al. In the postabsorptive state, approximately 50 percent of glucose production comes from glycogenolysis in liver and 50 percent from gluconeogenesis in the liver (Chandramouli et al. The minimal amount of carbohydrate required, either from endogenous or exogenous sources, is determined by the brain’s requirement for glucose. The brain is the only true carbohydrate-dependent organ in that it oxidizes glucose completely to carbon dioxide and water. The endogenous glucose production rate in a postabsorptive state correlates very well with the esti- mated size of the brain from birth to adult life. The requirement for glucose has been reported to be approximately 110 to 140 g/d in adults (Cahill et al. Nevertheless, even the brain can adapt to a carbohydrate-free, energy-sufficient diet, or to starvation, by utilizing ketoacids for part of its fuel requirements. When glucose produc- tion or availability decreases below that required for the complete energy requirements for the brain, there is a rise in ketoacid production in the liver in order to provide the brain with an alternative fuel. It is associated with approximately a 20 to 50 percent decrease in circulating glucose and insulin concentration (Carlson et al. These are signals for adipose cells to increase lipolysis and release nonesterified fatty acids and glycerol into the circulation. The signal also is reinforced by an increase in circulat- ing epinephrine, norepinephrine, glucagon, and growth hormone con- centration (Carlson et al. The nonesterified fatty acids are removed by the liver and converted into ketoacids, which then diffuse out of the liver into the circulation. The increase in nonesterified fatty acids results in a concentration-dependent exponential increase in ketoacids (Hanson et al. In individuals fully adapted to starvation, ketoacid oxidation can account for approximately 80 percent of the brain’s energy requirements (Cahill et al. This is similar to the total glucose oxidation rate integrated over 24 hours determined by isotope-dilution studies in these starving individuals (Carlson et al. Overall, the key to the metabolic adaptation to extended starvation is the rise in circulating nonesterified fatty acid concentrations and the large increase in ketoacid production. The glycerol released from the hydrolysis of triacylglycerols stored in fat cells becomes a significant source of sub- strate for gluconeogenesis, but the conversion of amino acids derived from protein catabolism into glucose is also an important source. Interestingly, in people who consumed a protein-free diet, total nitrogen excretion was reported to be in the range of 2. Overall, this represents the minimal amount of protein oxi- dized through gluconeogenic pathways (Du Bois, 1928). For a 70-kg lean male, this equals 56 g/d of protein, which is greater than the estimated obligate daily loss in body protein from the shedding of cells, secretions, and other miscellaneous functions (approximately 6 to 8 g/d for a 70-kg man; see Chapter 10) and has been assumed to be due to inefficient utilization of amino acids for synthesis of replacement proteins and other amino acid-derived products (Gannon and Nuttall, 1999). In part, it also may represent the technical difficulty in determining a mini- mal daily protein requirement (see Chapter 10). If 56 g/d of dietary protein is required for protein homeostasis, but the actual daily loss of protein is only approximately 7 g, then presumably the remaining difference (49 g) is metabolized and may be utilized for new glucose production. Thus, from the 49 g of protein not directly utilized to replace loss of endogenous protein or not used for other synthetic processes, approximately 27 g (0. In people on a protein-free diet or who are starving, the 16 to 22 g of catabolized protein could provide 10 to 14 g of glucose. The glycerol content of a typical triacylglycerol is 10 percent by weight, or in this case 19 g of glycerol, which is equivalent to approximately 19 g of glucose.
Prevention Wash hands after touching anything that could be contaminated with secretions from the nose or mouth cheap atorlip-5 5 mg without prescription. Mosquito-borne diseases are viral diseases that are spread by infected mosquitoes cheap 5 mg atorlip-5 mastercard. The many viruses have the potential of causing serious disease affecting the brain and central nervous system. Removal of potential breeding sites is important in preventing the spread of mosquitoes. Birdbaths, wading pools, dog bowls, and other artificial containers of water should be emptied weekly to eliminate mosquito-breeding areas. Mosquitoes breed in water and artificial containers, especially flower pots, birdbaths, cans, children’s toys, wading pools, tire swings, old tires, or anything that will hold a small pool of water should be emptied or discarded. Rarely, swelling of the spinal cord and brain (encephalitis), inflammation of the ovaries (oophoritis) or breasts (mastitis), and deafness may occur. Other examples of how the virus can be spread is through sharing toys, beverage containers, eating utensils, and smoking materials (cigarettes), and kissing. Exclusion will last through at least 26 days after the onset of parotid gland swelling in the last person who developed mumps. A blood test specific for mumps antibody should be done as soon as possible after symptoms begin. Sometimes, healthcare providers will obtain a second blood test 2 to 3 weeks later. Encourage parents/guardians to keep their child home if they develop symptoms of mumps. Wash hands thoroughly with soap and warm running water after contact with secretions from the nose or mouth. If you think your child Symptoms has Mumps: Your child may have swollen glands in front of and below the ear. Childcare and School: Contagious Period Yes, until 5 days after For 2 days before until 5 days after swelling begins. Call your Healthcare Provider If two or more cases of If anyone in your home: mumps occur in your ♦ was exposed to mumps and has not had mumps or childcare or school, public mumps vaccine in the past. Prevention All children by the age of 15 months must be vaccinated against mumps or have an exemption for childcare enrollment. An additional dose of mumps is highly recommended for kindergarten or two doses by eighth grade enrollment. When a mumps outbreak is identified, exemptions in childcare centers or schools will not be allowed. Students who refuse immunization should be excluded until at least 26 days after the onset of parotitis in the last person with mumps in the affected school or childcare center. Norovirus is often incorrectly called the “stomach flu”, although it is not caused by the influenza virus. In addition, fever, headache, muscle aches, fatigue, and stomach cramps can occur. The illness can be mild to moderately severe with symptoms usually lasting 24 to 48 hours. Spread can occur when people do not wash their hands after using the toilet or changing diapers. People can also get sick by eating food items contaminated during preparation or serving. Person-to-person spread often occurs within families, schools, nursing homes, cruise ships, in childcare settings, and communities. No one with vomiting and/or diarrhea should use pools, swimming beaches, recreational water parks, spas, or hot tubs for 2 weeks after diarrhea and/or vomiting symptoms have stopped. Staff must avoid food preparation when diarrhea and vomiting are present and for at least 3 days after diarrhea and/or vomiting have stopped. Wash hands thoroughly with soap and warm running water after using the toilet and changing diapers and before preparing or eating food. Staff should closely monitor or assist all children, as appropriate, with handwashing after children have used the bathroom or been diapered. In the classroom, children should not serve themselves food items that are not individually wrapped. If you think your child Symptoms has Norovirus: Your child may have watery diarrhea, vomiting, and Tell your childcare fever. Other symptoms may include headache, stomach provider or call the cramps, and tiredness. Childcare and School: Spread Yes, until the child has been free of diarrhea and vomiting for at least - By eating or drinking contaminated food or beverages.
If police target minority neighborhoods for drug arrests cheap atorlip-5 5 mg without a prescription, the drug offenders they encounter will be primarily black or Hispanic generic atorlip-5 5mg fast delivery. Darker faces become the faces of drug offenders, which may also contribute to racial profiling. Extensive research shows that police are more likely to stop black drivers than whites, and they search more stopped blacks than whites, even though they do not have a valid basis for doing so. Similarly, blacks have been disproportionately targeted in “stop and frisk” operations in which police searching for drugs or guns temporarily detain, question, and pat down pedestrians (Fellner 2009). Although police generally find drugs, guns, or other illegal contraband at lower rates among the blacks they stop than the whites, the higher rates at which blacks are stopped result in greater absolute numbers of arrests (Tonry 2011). Race becomes one of the readily observable visual clues to help identify drug suspects, along with age, gender, and location. There is a certain rationality to this—if you are in poor black neighborhoods, drug dealers are more likely to be black” (1998, p. Katherine Beckett and her colleagues showed that drug arrests in Seattle reflected racialized perceptions of drugs and their users (Beckett et al. Although the majority of those who shared, sold, or transferred serious drugs were white, almost two-thirds (64. Black drug sellers were overrepresented among those arrested in predominantly white outdoor settings, in racially mixed outdoor settings, and even among those who were arrested indoors. Three- quarters of outdoor drug possession arrests involving powder cocaine, heroin, crack cocaine, and methamphetamines were crack-related even though only one-third of the transactions involved that drug. The disproportionate pattern of arrests resulted from the police department’s emphasis on the outdoor drug market in the racially diverse downtown area of the city, its lack of emphasis on outdoor markets that were predominantly white, and, most important, its emphasis on crack. Crack was involved in one-third of drug transactions but three-quarters of drug delivery arrests; blacks constituted 79 percent of crack arrests. The researchers could not find racially neutral explanations for the police emphasis on crack in arrests for drug possession or sale, or for the concentration of enforcement activity in the racially diverse downtown area rather than predominantly white outdoor areas or indoor markets. These emphases did not appear to be products of the frequency of crack transactions compared to other drugs, public safety or public health concerns, crime rates, or citizen complaints. The researchers concluded that the choices reflected ways in which race shapes police perceptions of who and what constitutes the most pressing drug problems. Blacks are disproportionately arrested in Seattle because of “the assumption that the drug problem is, in fact, a black and Latino one, and that crack, the drug most strongly associated with urban blacks, is ‘the worst’” (Beckett et al. In 2010, as Table 4 shows, cocaine (including crack) and heroin arrests accounted for 22. Blacks were more likely than whites to report using heroin, but the percentages are quite low: 1. The proportion of drug arrests for cocaine and heroin thus seem to bear only a slight relationship to the prevalence of their use. Boyum, Caulkins, and Kleiman (2011) observe that the enforcement of laws criminalizing cocaine accounts for “about 20 percent of the nation’s law enforcement, prosecution, and corrections” (p. Subscriber: Univ of Minnesota - Twin Cities; date: 23 October 2013 Race and Drugs Table 4 Arrests by Type of Offense, Drug, and Race, 2010 White Black Native American Asian Total Sales Cocaine/Heroin 34,787 45,635 346 351 81,119 42. All other things being equal, one would expect the racial distribution of prisoners sentenced for particular crimes to reflect the racial distribution of arrests for those crimes. Blumstein showed in 1982 that about 80 percent of racial differences in incarceration in 1979 could be accounted for by differences in arrest (Blumstein 1982). In the case of drug offenses, there was a significant difference between the racial breakdowns of arrests and incarceration. Racial disparities in imprisonment for drug crimes are even greater than disparities in arrest. There are significant racial differences at different decision points in criminal justice processing of cases following arrest. Those differences compound, ultimately producing stark differences in outcomes (Kochel, Wilson, and Mastrofski 2011; Spohn 2011). In Illinois, for example, even after accounting for possible selection bias at each stage of the criminal justice system, nonwhite arrestees were more likely than whites to have their cases proceed to felony court, to be convicted, and to be sent to prison (Illinois Disproportionate Impact Study Commission 2010). After controlling for other variables, including criminal history, African Americans in Cook County, Illinois were approximately 1. Subscriber: Univ of Minnesota - Twin Cities; date: 23 October 2013 Race and Drugs Spohn 2011). Young African-American men in Ohio had lower odds of pretrial release on their own recognizance, had higher bond amounts, and higher odds of incarceration relative to other demographic subgroups (Wooldredge 2012). The exercise of federal prosecutorial discretion with respect to charging decisions, motions for mitigated sentences based on substantial assistance by the defendant in the prosecution of others, and plea bargaining has led to racial disparities that affect sentences (Baron-Evans and Stith 2012, pp. Rehavi and Starr (2012) found that federal prosecutors were more likely to charge more serious offenses against black than white arrestees, including for offenses carrying mandatory minimum penalties. Ulmer and his colleagues found racial differences in downward departures under the federal guidelines, whether initiated by prosecutors or judges (Ulmer, Light, and Kramer 2011).
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